Respected Sir(2): magic target for diabetes.
نویسندگان
چکیده
The endless quest for the 'fountain of youth' has led to the discovery of a family of molecules known as sirtuins in humans, or silent mating type information regulator 2 (Sir2) in yeast, which are associated with longevity in yeast, nematodes, drosophila and rodents. Although sirtuins have yet to be proven to delay aging and promote longevity in humans, they promise 'healthy aging', an ideal of modern society. This review emphasizes the role of various sirtuins in maintaining glucose homeostasis, the therapeutic potential of sirtuin modulators in the prevention and treatment of diabetes, and the emerging associations of SIRT genetic polymorphisms with human longevity.
منابع مشابه
Application of Non-Linear Functions at Distribution of Output SINR Gaussian Interference Channels
We have examined the convergence behavior of the LSCMA in some simple environments. Algorithms such as Multi¬ Target CMA, Multistage CMA, and Iterative Least Squares with Projection can be used for this purpose. The results presented here can form a basis for analysis of these multi-signal extraction techniques. Clearly, the variance and distribution of output SINR obtained with the LSCMA is al...
متن کاملThe feasibility of direct treatment planning via contrast-enhanced computed tomography: an evaluation of dose differences based on the dimensional dose distribution comparison method
Background: We used a MapCHECK software-based dimensional dose distribution comparison method capable of evaluating point-to-point geometrical dose differences in volume to determine whether doses obtained from an enhanced computed tomography (CT)-based treatment plan, which better defines the target regions and organs at risk, differs from doses obtained from plain CT and then evaluated the fe...
متن کاملIncreased cancer incidence risk in type 2 diabetes mellitus: results from a cohort study in Tyrol/Austria
BACKGROUND Recent meta-analyses revealed an association between type 2 diabetes mellitus (T2DM) and cancer. The strongest relationship was demonstrated for liver and pancreatic cancer, followed by endometrial cancer. We aimed at assessing the association between T2DM and cancer specifically for Tyrolean patients. METHODS We investigated cancer incidence in Tyrolean subjects with T2DM by linki...
متن کاملPSMA-PET for Lymph Node Detection in Recurrent Prostate Cancer: How do we use the Magic Bullet?
1. Department of Urology, Technical University of Munich, Munich, Germany 2. Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Australia; Australian Prostate Cancer Research Centre, Epworth Healthcare, Richmond, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne 3. Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Australia; The Sir Pe...
متن کامل$Z_k$-Magic Labeling of Some Families of Graphs
For any non-trivial abelian group A under addition a graph $G$ is said to be $A$-textit{magic} if there exists a labeling $f:E(G) rightarrow A-{0}$ such that, the vertex labeling $f^+$ defined as $f^+(v) = sum f(uv)$ taken over all edges $uv$ incident at $v$ is a constant. An $A$-textit{magic} graph $G$ is said to be $Z_k$-magic graph if the group $A$ is $Z_k$ the group of integers modulo $k...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cellscience
دوره 4 4 شماره
صفحات -
تاریخ انتشار 2008